Desperate Housewives | Teri Hatcher as Susan Mayer
Susan writes books for children. She has a daughter named Julie. She is clumsy and a divorcee to Karl Mayer. She is keenly attracted to their new neighbor, Mike Delfino. |
 | Felicity Huffman as Lynette Scavo
Wife to Tom Scavo and a mother of 3 hyper-boys. Lynette had to give up her successful job in order to become a housewife which turns out to be a disaster. She is one of Mary Alice's closest friends. |
 | Marcia Cross as Bree Van der Camp
Born in 1962, Bree is a White Anglo-Saxon Protestant. Bree is recognized for her perfectionist attitude and work ethic, which at times borders on neurosis and obsessive compulsion. |
 | Eva Longoria as Gabrielle Solis
Gabrielle Marquez or Gabby was a former New York ramp model. She gave up her career and marry the rich Carlos Solis. She loves shopping and is one of the things she does to occupy herself while her husband is away all the time. The other thing is sleeping with their young gardener, John Rowland. |
 | Nicollette Sheridan as Edie Britt
Edie Britt is the neighborhood slut. She had been known for sleeping with young men, married men, and even a priest. She is bestfriend to Martha Huber and has a habit of blackmailing people to get what she wants. |
Brenda Strong as Mary Alice Young
Mary Alice Young darkly narrates the happenings on Wisteria Lane even after her death. Her mysterious suicide was explored during the first season of the show.  | Ricardo Antonio Chavira as Carlos Solis
He is husband to Gabrielle Solis. He does business transaction with clients all the time thus forgetting to tend the needs of his wife. He is a jealous and romantic man and what he wants more than anything was to have a child. |
James Denton as Mike Delfino
One of Wisteria Lane's newest faces, Mike Delfino is a plumber and the source of rivalry between Susan Mayer and Edie Britt. His presence in this suburbian community is no coincidence. Drea de Matteo as Angie Bolen  | Doug Savant as Tom Scavo
Tom has 4 children with his wife, Lynette. He is always seen being undermined by his wife. Tom has been known to be very faithful to his wife. But he has a secret he's been keeping from her which Lynette later found out. |
 | Shawn Pyfrom as Andrew Van de Kamp
The rebellious son of Bree and Rex van der Camp. If Andrew were to choose which of his parents he loves best, he would choose his father. He hates her mother's stepford-attitude. In the later episode, Andrew revealed that he likes other boys. |
Andrea Bowen as Julie Mayer
The perfect daughter to her clutsy mother, Susan. She always do her homework before bedtime, help with her mother's accounting, and even fixes her mother's love life. Joy Lauren as Danielle Van De Kamp
Daughter of Bree and Rex van der Camp, Danielle has only one thing in her mind... herself. Unlike her brother, she does not care about her mother's obsession as long as she gets what she wants. Cody Kasch as Zach Young
Zach is the son of Mary Alice and Paul Young. He loves her mother so much and felt a certain guilt on her mother's suicide. The real nature of his existence is revealed later in the series. Mark Moses as Paul Young
Husband to the late Mary Alice Young, Paul bodes mystery to the neighbors of Wisteria Lane. He isolates himself and his son from the crowd, afraid that they might find out their little secret. Richard Burgi as Karl Mayer
Ex-husband to Susan Mayer, Karl pays Susan alimony while he dates his secretary. He still loves his ex-wife and would have given their marriage a chance if only his "manhood" agrees with him. Kyle MacLachlan as Orson Hodge
The mystery of Orson Hodge was explored during the third season of the series. He is a widower and was first introduced in the series as Susan's fake date in a movie house.  | Dana Delany as Katherine Mayfair
Katherine became Bree's competitor as the town's perfect housewife. Her appearance in the series was explored duing the series's fourth season. Just like Bree, she loves to cook while taking care of her husband and daughter. |
Steven Culp as Rex Van de Kamp
Rex has two children and a husband to Bree van der Camp. He has special needs his wife was unable to give him. He loves Bree but hates her compulsive obsession to clean everything in sight. Jesse Metcalfe as John Rowland
The young stud that serves the Solis household as a gardener. When Mrs. Solis's husband is away, he would enter her bedroom and served the housewife even more to her husband's satisfaction. He loves Gabrielle even though he knows she is married.  | Neal McDonough as Dave Williams
Season five's major story arc focus on the Dave Williams's agenda to move to Wisteria Lane. On the outside, he looks calm, composed, and seem to know the right things to say. On the inside is a secret he's been keeping from his neighbors and his wife. |
Mehcad Brooks as Matthew Applewhite
Matthew is Betty's son who also moved into the neighborhood. She follows whatever her mother told her to do but has a sinful past he's been keeping even from his mother. Alfre Woodard as Betty Applewhite
Betty was a former pianist who just moved in to Wisteria Lane together with her son. Her sudden change of home and the secrets she's been keeping is further explored in the second season of the series. Dougray Scott as Ian Hainsworth
Ian's wife is in comma. He has been in despair for many years until he met Susan Mayer. He is a wealthy British businessman who often travels in and out of the country. Josh Henderson as Austin McCann
Austin is Edie's nephew. He just got out of juvenile prison. He has a love/hate relationship with Susan's daughter, Julie. Roger Bart as George Williams
George is a pharmacist who has a deep and longing crush on Bree van der Camp. He made her move on Bree the moment he found out that Bree and her husband are having marital problems. Lyndsy Fonseca as Dylan Mayfair Maiara Walsh as Ana Solis Brent Kinsman as Preston Scavo Shane Kinsman as Porter Scavo Zane Huett as Parker Scavo Rachel Fox as Kayla Scavo Charlie Carver as Porter Scavo Max Carver as Preston Scavo Joshua Logan Moore as Parker Scavo Kendall Applegate as Penny Scavo | 
