Empty Nest (1988)

Widowed pediatrician Harry Weston is a miracle worker when it comes to dealing with his young patients, but he's more challenged by the other people surrounding him: daughters Barbara and Carol, the first a brash undercover cop, the second a neurotic divorcee; his wisecracking office assistant, Nurse LaVerne Todd; and obnoxious neighborhood mooch Charley Dietz. Thank goodness he always finds a friendly shoulder (and a warm, wet tongue) in Dreyfuss, his enormous dog.