Grey's Anatomy

Cast and Crew

Patrick Dempsey auditioned for the role of Dr. Chase on FOX's prime time medical mystery show, House, before taking the role of Dr. Shepherd.
The character name Dr. Mark Sloan is a reference to a 'Dick Van Dyke' character by the same name in the TV show '"Diagnosis Murder" (1993)'.
Kate Walsh's character, Addison Shepherd, was only supposed to appear in 5 episodes, but quickly developed a fan base so they kept her on.
The character Alex Karev was not in the original pilot script; his role was inserted into the pilot as an afterthought in order to provide a foil, as well as male companionship for Dr. George O'Malley. Since he wasn't added until after the pilot was shot, scenes with him were either re-shoots or digitally altered.
Rob Lowe was originally considered for the role of Derek Shepherd, but passed on it.

Episodic

Every episode shares the name with a song title by a popular artists. Several are named after The Beatles and R.E.M. songs.

Production

In order to keep the plot and storylines secret, in the sides for auditions, the main characters' names are changed.

Reference

The show's title is a reference to the famous anatomy book "Gray's Anatomy of the Human Body" by Henry Gray.