| | Heroes | Jack Coleman as Noah Bennet More commonly referred to as "Mr. Bennet" or "the Man in Horn-Rimmed Glasses (H.R.G.)", initially worked for the Primatech Paper Company, which is actually a cover operation for an organization that investigates people with superhuman abilities. |
 | Sendhil Ramamurthy as Mohinder Suresh A professor of genetics from India who travels to New York to investigate the death of his father, Chandra. Through his investigations, he comes into contact with people his father listed as possessing superhuman abilities. Mohinder's blood contains antibodies against a virus which only infects people with special abilities. |
 | Hayden Panettiere as Claire Bennet A high school cheerleader formerly of Odessa, Texas, now living in Costa Verde, California, who has a spontaneous regenerative ability. She is Mr. Bennet's adopted daughter, as well as Nathan Petrelli's biological daughter. |
 | Milo Ventimiglia as Peter Petrelli A former hospice nurse with the ability to absorb the powers of others he has been near and recall them. |
 | Masi Oka as Hiro Nakamura A programmer from Osaka with the ability to manipulate the space-time continuum. He is convinced that he is a hero, and with other "special persons", he can change the future. |
 | Adrian Pasdar as Nathan Petrelli A former New York Congressional candidate with the ability of self-propelled flight. |
Ali Larter as Niki Sanders/Tracy Strauss Ali Larter as Niki Sanders/Tracy Strauss  | Greg Grunberg as Matt Parkman A former Los Angeles police officer with the ability to hear other people's thoughts, though his powers are developing further, such as his ability to control people's actions. He is currently an NYPD detective and the guardian of Molly Walker. |
 | Ali Larter as Niki Sanders / Jessica Sanders A former internet stripper from Las Vegas who exhibits superhuman strength and has multiple personalities. She has shown two alternate personalities: Jessica, the name of Niki's dead sister and Gina, who appeared in Four Months Ago.... She is D.L.'s wife and Micah's mother. |
 | Noah Gray-Cabey as Micah Sanders A child prodigy and technopath, he has the ability to "talk" to electrical devices, giving him control of machines and electronic devices. He is D.L. and Niki's son. |
 | Tawny Cypress as Simone Deveaux An art dealer and gallery owner whose skepticism and complicated romantic life are tested. |
 | James Kyson Lee as Ando Masahashi Hiro Nakamura's friend, coworker, and traveling companion. He has no known superhuman abilities. |
 | Zachary Quinto as Sylar Real name Gabriel Gray, a former watchmaker with an intuitive understanding of how things work. He is a serial killer who seeks out superhuman individuals, killing them in order to take their powers. Sylar has multiple acquired abilities. Sylar takes his alias from the brand name of a watch company. |
 | Leonard Roberts as D.L. Hawkins A former construction worker and gang leader with the power to alter his physical tangibility and phase through solid objects. He is Niki's husband and Micah's father. |
 | Santiago Cabrera as Isaac Mendez An artist living in New York who can paint future events during precognitive trances. He also writes and draws a comic book called 9th Wonders! which has also been shown to depict the future. |
 | Dania Ramirez as Maya Herrera From Central America, is wanted for murder and is on the run to the United States. Under stress, Maya can create a deadly illness when she cries which is fatal to those around her, except her twin brother Alejandro, who can heal it. |
 | David Anders as Adam Monroe An Englishman who originates the role of legendary warrior Kensei in feudal Japan. Monroe has a spontaneous regenerative ability which has made him effectively immortal. |
 | Kristen Bell as Elle Bishop A 24 year old woman who works for The Company. Her father, Bob Bishop, is head of The Company. She has the power of electric manipulation. |
 | Dana Davis as Monica Dawson A restaurant worker at the Burger Bonanza in New Orleans. She is D.L. Hawkins' niece and Micah's first cousin. Monica has the ability of adoptive muscle memory: she can replicate any physical motion she witnesses. |
 | Cristine Rose as Angela Petrelli Loving mother to her sons, Angela holds a secret from Nathan and Peter which were later revealed in season 2 and 3. She encouages Nathan to pursue his political career. |
 | Ali Larter as Tracy Strauss She looks like Nikki Sanders but she is not Nikki Sanders. She has a different ability of her own. She works as an adviser to a New York governor |
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