| | Iisa Pa Lamang | Claudine Barretto as Catherine Ramirez
A young woman who became a victim of wrong love and oppression. She will vow vengeance against Isadora and Miguel. |
 | Gabby Concepcion as Rafael Torralba
The best friend of Miguel. He also harbors special feelings for Catherine, but his love will remain unrequited because of inevitable circumstances. |
 | Diether Ocampo as Miguel Castillejos
The former love of Catherine and now the husband of Scarlet. He is confused if it is hate or love that he feels for Catherine. |
 | Angelica Panganiban as Scarlet dela Rhea
The wife of Miguel. She will punish Catherine for marrying her father and having a past affair with her husband. |
 | Melissa Ricks as Sofia Castillejos
The younger sister of Miguel. She is affected by the problems of her mother and brother. Sophia will eventually find herself attracted to Toby. |
Matt Evans as Toby Torralba
The younger brother of Rafael. He will feel neglected in the family but will later fall in love with Sophia. Laurice Guillen as Estelle Torralba
Rafael's mother. Cherry Pie Picache as Isadora Castillejos
The greedy and scheming mother of Miguel and Sophia. In the name of wealth and power, she will cause Catherine pain and misery.  | Ms. Susan Roces as Lola Aura
The grandmother of Catherine. She will serve as Catherine's moral compass amidst the life filled with betrayal and vengeance. |
Joel Torre as Rolando Ramirez
Catherine's father. |
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