Medium

Patricia Arquette as Allison DuBois
A dedicated wife and mother, who also happens to be a gifted psychic able to communicate with the dead.

Jake Weber as Joe DuBois
An aerospace engineer and supportive, loving husband and father to psychic Allison Dubois and their three girls.

Sofia Vassilieva as Ariel DuBois
Allison and Joe's eldest daughter who exhibits some of the same psychic abilities as her mother. Fifteen-year old Ariel continues to struggle to balance her life as an everyday suburban teenager with her mysterious, emerging inherited gifts.

Maria Lark as Bridgette DuBois
Allison and Joe's precocious middle daughter who has begun to exhibit the same psychic gifts as her mother.

Miguel Sandoval as Manuel Devalos
A traditional by-the-book lawyer and Phoenix District Attorney who early on recognized something special in Allison and continues to trust her psychic leads.

David Cubitt as Lee Scanlon
a Phoenix police detective who has come to respect Allison's knack for seeing what he can't and intuiting things that seem to elude others. Scanlon initially did not believe in her "gift."