| | Monk | Tony Shalhoub as Adrian Monk Adrian Monk has many clinical mental disorder from a variety of phobias to Obsessive Compulsive Disorder. Despite this, he is an excellent detective who is always able to solve a case. |
 | Traylor Howard as Natalie Teeger Adrian Monk's devoted personal assistant, a strong, self-reliant single mom whose tough love proves to be exactly what Monk needs. Though often frustrated and confused by her boss's peculiar behavior, Natalie remains a caring but firm assistant and friend, pushing Monk to overcome his debilitating fears and compulsions. |
 | Jason Gray-Stanford as Lt. Randall Disher Captain Stottlemeyer's eager but bumbling right-hand man. Ambitious, well-intentioned, and devoted to the Captain, Disher is a faithful "Boy Friday." Though competitive and even a little jealous of Monk, Disher lacks brilliance as a detective. |
 | Ted Levine as Captain Leland Stottlemeyer Adrian Monk's former partner and boss, the longtime friend who was ultimately forced to let Monk go from the San Francisco Police Department when his obsessive-compulsive disorder began to dangerously interfere with his work. |
 | Bitty Schram as Sharona Fleming Sharona is a divorced practical nurse from New Jersey and a single mother with a young son named Benjy. She works for Adrian Monk as an assistant. She was always on hand to offer her assistance when even the simplest of tasks became angst-ridden ordeals for Monk. |
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