Prison BreakWentworth Miller as Michael Scofield
The protagonist, brother of Lincoln Burrows. He designs an escape plan to free his brother and save his life. He successfully executes this plan, but fails to evade the police in Panama. Currently incarcerated at Sona. Dominic Purcell as Lincoln Burrows
Falsely accused of the murder of Terrence Steadman and sentenced to death for the crime. He evaded authorities after escaping from prison and has been exonerated of all charges. Currently free, he assisting Michael and James Whistler break out of Sona. Robert Knepper as Theodore "T-Bag" Bagwell
Imprisoned at Fox River State Penitentiary with a life sentence for six accounts of kidnapping, rape, and murder. He escapes with Michael's help and reconnects with his previous family by kidnapping them. He then frees them after an emotional outbreak, before ending up in Sona for his role in the murder of prostitutes. Wade Williams as Brad Bellick
Leader of the Fox River State Penitentiary correctional officers but is later dismissed. He goes after Charles Westmoreland's hidden five million dollars, but fails. Set up for murder twice by T-Bag, he is currently incarcerated at Sona. Amaury Nolasco as Fernando Sucre
Imprisoned at Fox River State Penitentiary for aggravated robbery and was Michael Scofield's cellmate. Escapes prison and briefly reconnects with his fiance and mother of his child, Maricruz. Sarah Wayne Callies as Dr. Sara Tancredi
Michael's love interest and a doctor working at Fox River State Penitentiary before becoming involved in the conspiracy behind Lincoln Burrows' setup. Paul Adelstein as Paul Kellerman
Secret Service agent who was ordered to make sure Lincoln Burrows is framed and convicted for murder, along with various other illegal acts. His current status is unknown (but presumed dead after a shooting) after releasing information about The Company at Sara Tancredi's trial. Marshall Allman as L. J. Burrows
Son of Lincoln Burrows who evades corrupted Secret Service agent, Paul Kellerman. He eventually begins school again with a new identity until he is kidnapped by the company. William Fichtner as Alexander Mahone
F.B.I. Special Agent, who is put in charge of the nationwide manhunt for the Fox River escapees. He is responsible for the deaths of three of the Fox River Eight. In turn, Michael sets him up for possession of cocaine, which leads to his incarceration at Sona as well. Rockmond Dunbar as Benjamin Miles "C-Note" Franklin
Imprisoned at Fox River for possession of stolen goods. He escapes prison and reconnects successfully with his family. All charges against him are dropped after he reveals certain secrets about Alexander Mahone. Robin Tunney as Veronica Donovan
A real-estate lawyer and a longtime friend of the protagonists of the series, who unsuccessfully tries to find evidence to exonerate Lincoln. She was executed by secret service agents after finding Steadman. Stacy Keach as Henry Pope
Served as Warden at Fox River State Penitentiary. Danay Garcia as Sofia Lugo
Girlfriend of James Whistler. Chris Vance as James Whistler
Incarcerated at Sona and the one that The Company wants Michael to break out. Robert Wisdom as Norman St. Jones / Lechero
A Panamanian drug kingpin incarcerated at Sona; leader of the prison. Jodi Lyn O'Keefe as Susan B. Anthony
She is a merciless and an impatient woman who performs swift executions without hesitation if there is any obstacle to her plan. Michael Rapaport as Agent Don Self Peter Stormare as John Abruzzi
A mob boss who is imprisoned at Fox River State Penitentiary with a life sentence. He is shot and killed after escaping prison. | 
